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Blunck, Rikard

Professeur titulaire

  • Professeur affilié du Département de physiologie moléculaire, cellulaire et intégrative
  • Professeur affilié du Département de biochimie et médicine moléculaire

Contact :

  • Téléphone 514-343-7960 Pav. PAVILLON PAUL-G. DESMARAIS \ bur. 3137

Site Web

Blunck, Rikard

Présentation

Expertises de recherche

- canaux ioniques / éléctrophysiologie

- toxines formeuses de pores

- spectroscopie de fluorescence en voltage imposé

- fluorescence des molécules unitaires

Champs d'expertise

Publications principales

1: Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F. Gating charge
displacement in voltage-gated ion channels involves limited transmembrane
movement. Nature. 2005 Aug 11;436(7052):852-6. PubMed PMID: 16094369.


2: Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F. A hybrid
approach to measuring electrical activity in genetically specified neurons. Nat
Neurosci. 2005 Nov;8(11):1619-26. Epub 2005 Oct 2. PubMed PMID: 16205716.


3: Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F. Detection of
the opening of the bundle crossing in KcsA with fluorescence lifetime
spectroscopy reveals the existence of two gates for ion conduction. J Gen
Physiol. 2006 Nov;128(5):569-81. Epub 2006 Oct 16. PubMed PMID: 17043150; PubMed 
Central PMCID: PMC2151582.


4: Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. 
Distance measurements reveal a common topology of prokaryotic voltage-gated ion
channels in the lipid bilayer. Proc Natl Acad Sci U S A. 2006 Oct
24;103(43):15865-70. Epub 2006 Oct 16. PubMed PMID: 17043236; PubMed Central
PMCID: PMC1635094.


5: Blunck R, McGuire H, Hyde HC, Bezanilla F. Fluorescence detection of the
movement of single KcsA subunits reveals cooperativity. Proc Natl Acad Sci U S A.
2008 Dec 23;105(51):20263-8. doi: 10.1073/pnas.0807056106. Epub 2008 Dec 11.
PubMed PMID: 19074286; PubMed Central PMCID: PMC2629256.


6: Batulan Z, Haddad GA, Blunck R. An intersubunit interaction between S4-S5
linker and S6 is responsible for the slow off-gating component in Shaker K+
channels. J Biol Chem. 2010 Apr 30;285(18):14005-19. doi:
10.1074/jbc.M109.097717. Epub 2010 Mar 4. PubMed PMID: 20202932; PubMed Central
PMCID: PMC2859562.


7: Groulx N, Juteau M, Blunck R. Rapid topology probing using fluorescence
spectroscopy in planar lipid bilayer: the pore-forming mechanism of the toxin
Cry1Aa of Bacillus thuringiensis. J Gen Physiol. 2010 Nov;136(5):497-513. doi:
10.1085/jgp.200910347. PubMed PMID: 20974771; PubMed Central PMCID: PMC2964520.


8: Haddad GA, Blunck R. Mode shift of the voltage sensors in Shaker K+ channels
is caused by energetic coupling to the pore domain. J Gen Physiol. 2011
May;137(5):455-72. doi: 10.1085/jgp.201010573. PubMed PMID: 21518834; PubMed
Central PMCID: PMC3082931.


9: Wall-Lacelle S, Hossain MI, Sauvé R, Blunck R, Parent L. Double mutant cycle
analysis identified a critical leucine residue in the IIS4S5 linker for the
activation of the Ca(V)2.3 calcium channel. J Biol Chem. 2011 Aug
5;286(31):27197-205. doi: 10.1074/jbc.M111.237412. Epub 2011 Jun 7. PubMed PMID: 
21652722; PubMed Central PMCID: PMC3149313.


10: Kalstrup T, Blunck R. Dynamics of internal pore opening in K(V) channels
probed by a fluorescent unnatural amino acid. Proc Natl Acad Sci U S A. 2013 May 
14;110(20):8272-7. doi: 10.1073/pnas.1220398110. Epub 2013 Apr 29. PubMed PMID:
23630265; PubMed Central PMCID: PMC3657800.


11: Faure É, Starek G, McGuire H, Bernèche S, Blunck R. A limited 4 Å radial
displacement of the S4-S5 linker is sufficient for internal gate closing in Kv
channels. J Biol Chem. 2012 Nov 16;287(47):40091-8. doi: 10.1074/jbc.M112.415497.
Epub 2012 Sep 27. PubMed PMID: 23019337; PubMed Central PMCID: PMC3501078.


12: Blunck R, Batulan Z. Mechanism of electromechanical coupling in voltage-gated
potassium channels. Front Pharmacol. 2012;3:166. doi: 10.3389/fphar.2012.00166.
eCollection 2012. PubMed PMID: 22988442; PubMed Central PMCID: PMC3439648.


13: McGuire H, Aurousseau MR, Bowie D, Blunck R. Automating single subunit
counting of membrane proteins in mammalian cells. J Biol Chem. 2012 Oct
19;287(43):35912-21. doi: 10.1074/jbc.M112.402057. Epub 2012 Aug 28. PubMed PMID:
22930752; PubMed Central PMCID: PMC3476259.


14: Groulx N, McGuire H, Laprade R, Schwartz JL, Blunck R. Single molecule
fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals
tetramerization. J Biol Chem. 2011 Dec 9;286(49):42274-82. doi:
10.1074/jbc.M111.296103. Epub 2011 Oct 17. PubMed PMID: 22006922; PubMed Central 
PMCID: PMC3234970.

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